Chancellor Olaf Scholz’s announcement of the Zeitenwende upended 50 years of German Ostpolitik, challenging the fundamental premises upon which German policy toward both Russia and the broader European security order were based. After the Soviet collapse, Germany pursued a Russia-first policy in the post-Soviet space, and its relations with Russia’s neighbors—including Ukraine—were determined by the primacy of ties with Russia post German reunification. Since the full-scale Russian invasion of Ukraine on February 24, 2022, relations with Russia have dramatically deteriorated, and Germany’s support for Ukraine in the Russia-Ukraine War has assumed priority in Berlin’s remaining ties with Moscow. But though the German government has remained committed to this new policy, German public opinion remains divided over the reversal of Ostpolitik, and recent elections in the eastern Länder indicate growing support for parties which favor discontinuing support for Ukraine and restoring ties with Russia. The Zeitenwende could be reversed, depending on the outcome of the war in Ukraine and on domestic political developments both in Germany and in the United States. This chapter will examine the historical evolution of German-Russian ties and provide a scorecard for the economic, energy, and political impacts of the Zeitenwende. It will discuss the Russian view of Germany’s new policies and examine how Germany has supported Ukraine since February 2022. This chapter concludes with the implications of the Zeitenwende for new leadership in Washington and Berlin, and for future US-German cooperation on Russia and Ukraine.